Diagnosticul atrofiei multisistemică este un chalenge diagnostic deoarece nu există nici un test care să poată confirma cu siguranță diagnosticul la un pacient înca în viata. După menopauză, uterul are tendința să se atrofieze.
Căpitănescu, Răzvan G. During pregnancy complicated with maternal diabetes DMthe placenta suffers certain pathological, functional and structural changes.
DM wa DM was correlated with a rapid progressive microangiopathy and this, in turn, may be associated with capillary hypertension and changes in capillary permeability. The objective of the study is to identify the clinical correlations with influence on gestation in general, and on the placental structure in particular, in pregnancy associated with type 1 T1DMtype 2 T2DM and gestational diabetes mellitus GDM.
The impact of the endometrial dating histology conditions associated with DM on placenta has been analyzed and correlated with the ultrasound uSmorphological, histological and immunohistochemical study of the placental structure. Preexisting maternal hypertension, preeclampsia and obesity were the main associated conditions.
The uS examination of placental endometrial dating histology revealed an increase in placental thickness in the second trimester.
The macroscopic endometrial dating histology showed that the placentas of women with diabetes are heavier. Gross pathological analysis of maternal and fetal surfaces of placentas revealed subcortical or basal plaque fibrin deposition, and placental infarction or intervillous thrombosis.
From the microscopic point of view, the findings include fibrinoid necrosis, intervillous fibrosis, focal hyaline degeneration, villous immaturity, chorangiosis, placental calcifications, placental infarction or decidual vasculopathy.
Maternal hypertensive disorders amplify the spectrum of morphological changes in the placenta.
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Placental immaturity and villous capillary dysfunction dating programma vitaya characterized by increased angiogenesis and enhanced vascular permeability. The diabetic placenta does not show specific changes, but different associations may be a diabetic pathological pattern influenced by associated conditions, especially preeclampsia, obesity, dyslipidemias and the lack of euglycemia during pregnancy.